The San Francisco 49ers are set to face the Minnesota Vikings in a challenging matchup after their impressive 32-19 victory over the New York Jets in Week 1. The 49ers will be without star running back Christian McCaffrey, placing additional pressure on Jordan Mason, who had a standout performance with 147 rushing yards in the opener. Meanwhile, the Vikings, led by quarterback Sam Darnold, look to build on their dominant 28-6 win against the Giants, though they may be without rookie receiver Jordan Addison due to an ankle injury. Nick Bosa acknowledged the Vikings as a tougher opponent than the Jets, highlighting the difficulty of winning in Minnesota, where the 49ers haven't triumphed since 1992. Both teams will need to address their defensive strategies, particularly the 49ers against the Vikings' offense, which features high-caliber players like Justin Jefferson. With McCaffrey's status still uncertain, the outcome of this game remains highly anticipated.