Louisville Star Running Back Isaac Brown Out Indefinitely With Leg Injury

Louisville star running back Isaac Brown suffered a lower‑leg injury late in the Cardinals’ win at Virginia Tech and will miss Saturday’s game against Cal after coach Jeff Brohm said “Isaac will be out for a while,” with no firm timetable for his return. Brown has been a breakout sophomore this season with roughly 91 carries for about 782 yards (leading the nation at ~8.6 yards per carry) and five touchdowns, including three straight 100‑yard games. The injury creates depth concerns: Keyjuan Brown — who has stepped up with big recent performances — is expected to assume a larger workload while the staff hopes injured back Duke Watson can return. Louisville (No. 14) still won at Virginia Tech, but Brown’s absence is a significant blow to the Cardinals’ ACC title and College Football Playoff aspirations and could alter betting lines and matchup dynamics moving forward.