A recent study published in The Lancet warns that antibiotic-resistant infections could lead to over 39 million deaths globally over the next 25 years, with the highest burden expected in South Asia. The research, conducted by the Global Research on Antimicrobial Resistance (GRAM) Project, highlights that more than one million deaths per year were already linked to antimicrobial resistance (AMR) from 1990 to 2021. Projections indicate that annual direct deaths from AMR could rise to 1.91 million by 2050, alongside an increase in AMR-associated deaths from 4.71 million to 8.22 million. While deaths among children under five are expected to decline, those among individuals aged 70 and older are projected to more than double. The study emphasizes the urgency for global interventions, including infection prevention, responsible antibiotic use, and research into new treatments to mitigate the impending crisis. Immediate action is needed as global health leaders prepare to discuss strategies to combat AMR at the upcoming UN General Assembly.