Multiple NFL Teams Face Key Injuries Ahead Week 4 Matchups

The Buffalo Bills are facing significant injury challenges ahead of their game against the New Orleans Saints, with key players Ed Oliver and Matt Milano ruled out, and Spencer Brown and A.J. Epenesa listed as questionable due to calf and pectoral injuries respectively. Despite extra rest days, recovery has been slow, complicating the team's depth and game-day decisions. Similarly, the Colorado Buffaloes are heavily impacted by injuries ahead of their matchup with BYU, missing multiple players including key running backs Simeon Price and Dekalon Taylor, which will place more pressure on remaining players like Micah Welch and Kaidon Salter. Colorado's secondary and defensive line are also depleted, with several players out or doubtful, posing a significant test for Coach Deion Sanders' squad. The Seattle Seahawks face their own offensive line depth concerns due to injuries to Josh Jones and Anthony Bradford, leading to the elevation of practice squad player Shane Lemieux to potentially fill in at guard, highlighting the vulnerability of their backup options. These injury issues across teams underscore the challenges NFL and college football teams face in maintaining competitive lineups amid mounting physical setbacks.