Major League Baseball Commissioner Rob Manfred has expressed concerns about player safety due to threats arising from gambling activities. Players have reported receiving threats, leading to internal discussions on proactive measures by the league. The U.S. Supreme Court's decision to allow sports betting has raised additional challenges, with players facing suspensions and lifetime bans for gambling-related issues. Incidents like Shohei Ohtani's former interpreter being charged with fraud due to illegal gambling highlight the seriousness of the situation. Manfred believes the league's collaboration with gambling entities aids in enforcing policies, with penalties and investigations serving as deterrents against rule violations.