The Missouri Tigers achieved a commanding 38-0 victory over the Buffalo Bulls, marking their second consecutive shutout—a feat not accomplished since 1935. The Tigers excelled with five rushing touchdowns and a strong defensive performance, including an interception that stifled the Buffalo offense. Quarterback Brady Cook rebounded from a lackluster opening game, completing 28 of 36 passes for 228 yards and contributing two rushing touchdowns. Star receiver Luther Burden was sidelined due to illness, allowing other receivers like Wease to step up, with Wease leading the team with 149 receiving yards. Buffalo's quarterback C.J. Ogbonna struggled, recording only 74 total yards and an interception. This victory solidifies Missouri's position as a formidable contender in college football this season.