Grey's Anatomy Season 22 Premieres with Explosion Aftermath, Hospital Crisis

Grey's Anatomy Season 22 premieres on October 9, 2025, picking up directly after the explosive cliffhanger of Season 21 that left Grey Sloan Memorial Hospital in chaos. The season opener, titled "Only the Strong Survive," focuses on the immediate aftermath of the explosion, with characters like Meredith Grey and others struggling to locate each other and assess who survived. Showrunner Meg Marinis has promised intense, non-stop action and a storyline that explores both the hospital's long road to recovery and the hope found in trying times. The season will feature 18 episodes airing weekly on ABC, with next-day streaming on Hulu, and introduces new characters alongside returning favorites. Fans are anxiously speculating about possible major character deaths, particularly concerning Link, who was present during the crisis, though the show may employ a bait-and-switch narrative. Overall, Season 22 promises dramatic medical emergencies, personal stories, and hospital renovations as the team works to save lives amid ongoing challenges.