Northwestern: SuperAgers' Memory Linked to Genetics, Biology

A 25-year Northwestern University study has found that SuperAgers—people over 80 with youthful memory—possess unique brain features such as a thicker anterior cingulate cortex and show both resistance to and resilience against Alzheimer's-related amyloid plaques and tau tangles. Some SuperAgers accumulate these proteins but remain cognitively healthy, suggesting distinct biological mechanisms at work. Genetic factors may significantly contribute to their preserved memory, alongside common lifestyle traits like social engagement and active routines, though no single behavior is definitive. Brain autopsies revealed fewer neurofibrillary tangles in key neurons typically affected by Alzheimer's. The research challenges the belief that cognitive decline is inevitable with age and highlights new avenues for dementia prevention and treatment. Scientists hope that further study of SuperAgers will provide important insights for combating age-related memory loss.