In a historic upset, Louisville defeated No. 11 Clemson 33-21 at Memorial Stadium, marking the Cardinals' first victory over the Tigers in program history. Louisville quarterback Tyler Shough contributed significantly, scoring a touchdown and leading the team alongside running back Isaac Brown, who rushed for a career-high 151 yards and clinched the game with a late touchdown. Despite an early lead from Clemson, the Cardinals dominated the game, limiting the Tigers' offensive potential and ultimately breaking their streak of 22 consecutive night wins at home. The loss severely impacts Clemson's hopes for an ACC title and a College Football Playoff berth, as they now require external help after their first conference defeat. Louisville's win qualifies them for a bowl game, showcasing their resurgence under coach Jeff Brohm. The victory adds to Louisville's reputation for top-10 upsets, having previously defeated other ranked teams in recent years.