The upcoming college football matchup between No. 11 USC and No. 18 Michigan has generated significant interest as both teams prepare for their Big Ten opener on September 21. USC enters the game as a 6.5-point favorite after a strong start, including victories over LSU and Utah State, while Michigan has struggled with a shaky offense and a recent uninspired win against Arkansas State. Michigan's new quarterback, Alex Orji, will lead the offense following a tumultuous performance by Davis Warren, who threw three interceptions last week. Despite their strong rushing game, the Wolverines rank poorly in total offensive yards and passing efficiency. This historic clash marks USC's first Big Ten matchup and will take place at Michigan's famed Big House, a venue that offers a significant home-field advantage. Both teams aim to improve their standings, with USC looking to build on their momentum and Michigan hoping to rebound from recent underwhelming performances.