The Drew Barrymore Show is set to premiere its fifth season on September 9, featuring high-profile guests such as Gayle King, Dax Shephard, and many celebrities including Demi Moore and Chris Hemsworth. Valerie Bertinelli joins the show as a new member of the 'Drew Crew,' which includes other lifestyle experts. This season will introduce a new segment called 'Wellsdays,' focusing on health and wellness topics, while continuing popular segments like 'Drew-Gooders' and 'Design by Drew.' The show has already been renewed for a sixth season, ensuring its run through at least 2026. Fans and executives alike have expressed excitement over the show's return, praising Barrymore's unique talent and connection with her audience.